Cyclotron - ABT Molecular Imaging Inc.

The BG-75 produces PET biomarkers and radioisotopes on demand. An integrated solution, the BG-75 encompasses an entire PET production lab in a 300 square feet (30 sq meter) room. It includes a self-shielded mini-cyclotron for producing the positron emitting F-18 isotope and microchemistry system for labeling specific molecules with the positron emitting isotopes. The unique BG-75 system is significantly smaller, easier to install and simpler to operate than conventional cyclotrons.

Self-Shielding

FEATURES OF OUR COMPACT
SELF-SHIEL DING SOLUTION

  • Low power
  • Simple one button operation
  • Fast production of radioisotopes – dose available when needed
  • Designed for reliability
  • Easy access to target and ion source for simple replacement
  • Turbo pump vs oil based diffusion pump

Accelerator Specifications

ACCELERATOR SPECIFICATIONS OF THE BG-75 SELF-SHIELDED MINI-CYCLOTRON:

  • 7.5 MeV positive ion cyclotron
  • 3 internal targets
  • Production rate of 1.0 mCi/min [18F] fluoride Production rate of 1.0 mCi/min [18F] fluoride
  • 1.16 T magnet
  • 5 µA Beam current for F-18 production

Micro-Chemistry

ABT’s INTEGRATED SOLUTION INCLUDES MICRO-CHEMISTRY WITH AUTOMATED QUALITY CONTROL

  • Micro-Chemistry with single use Dose Synthesis Card
  • Replaceable precursor/reagent kits
  • Programmable and capable of producing any one or two step [18F] fluoride ion based process
  • Self-shielded, installed adjacent to the accelerator shield
  • [18F] FDG/NaF Module

Quality Control Features:

FEATURES OF OUR INTEGRATED QUALITY CONTROL MODULE

  • Automated quality control sample from final product vial
  • Quality control tests for each dose
  • Quality control tests based on pharmacopeial standards
  • Embedded methods
  • Ph, volatile organics, radiochemical and radionuclidic purity, organic solvents, color/clarity, filter integrity
  • HPLC, rad detector, ph meter, microsensors
  • Dose record for each dose generated

Self-Shielding

FEATURES OF OUR COMPACT
SELF-SHIELDING SOLUTION

  • Self-shielded, eliminating the need for a bunker to house the system.
  • Shield opens vertically for servicing and provides radiation protection of <1 mR per hour in the typical room size specified.
  • Micro-Chemistry module is also self-shielded and can be installed adjacent to the cyclotron shield for direct connection within the same room.

Comparison to Conventional Cyclotrons

With a smaller footprint, lower cost and compact size, the BG-75 Biomarker Generator offers unparalleled advantages when compared to conventional cyclotrons.

  BIO MARKER GENERATOR CONVENTIONAL CYCLOTRON
PET LAB FOOTPRINT 300 FT2 4,000 FT2
WEIGHT 24 TONS 50 TONS
PERSONNEL 1 FTE 4 FTE
OPERATING EXPENSES $150K/YR $600K/YR
REPETITIVE PRODUCTION CYCLE 30 MIN 3 HOURS

Space Requirements

The integrated BG-75 Biomarker Generator requires significantly less facility space than conventional cyclotrons, as demonstrated in the figure below.

ABT Advanced Biomarker Min Room Requirements
ABT Advanced Biomarker Min Room Requirements